rn1ca09 (Sino Biological)

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Sino Biological rn1ca09
Rn1ca09, supplied by Sino Biological, used in various techniques. Bioz Stars score: 94/100, based on 5 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/na+protein/Influenza+A+H1N1+(A%2FCalifornia%2F07%2F2009)+Neuraminidase+%2F+NA+Protein/pm41764724-54-24-28
Average 94 stars, based on 5 article reviews

rn1ca09 - by Bioz Stars, 2026-09

94/100 stars

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Recombinant:

Article Title: Vaccine-induced NA immunity decreases viral shedding, but does not disrupt chains of airborne transmission for the 2009 pandemic H1N1 virus in ferrets.
Article Snippet: .. Ferrets that received NA protein were vaccinated intramuscularly (i.m.) with 50 μg of baculovirus-expressed A/California/04/2009 N1 NA recombinant protein (Sino Biological Cat No.11058-V08B) generated with vasodilator-stimulated phosphoprotein tetrameriza tion domain at the N-terminus. .. The recombinant NA protein (specific activity >8,000 pmoles/min/μg using 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid substrate and >90% purity by SDS-PAGE) was mixed 1:1 with oil-in-water adjuvant, Sigma Adjuvant System (Sigma Aldrich).

Article Title: Novel mono- and multivalent N-acetylneuraminic acid glycoclusters as potential broad-spectrum entry inhibitors for influenza and coronavirus infection.
Article Snippet: N-acetylneuraminic acid (Neu5Ac) is a glycan receptor of viruses spread in many eukaryotic cells.. The present work aimed to design, synthesis and biological evaluation of a panel of Neu5Ac derivatives based on a cyclodextrin (CD) scaffold for targeting influenza and coronavirus membrane proteins.. The multivalent Neu5Ac glycoclusters efficiently inhibited chicken erythrocyte agglutination induced by intact influenza virus in a Neu5Ac density–dependent fashion.

Article Title: Understanding the treatment benefit of hyperimmune anti-influenza intravenous immunoglobulin (Flu-IVIG) for severe human influenza
Article Snippet: .. Recombinant HA proteins from the A/Cali09 virus and the B/Phuket virus, NA protein from the B/Phuket virus, and a negative control protein simian immunodeficiency virus gp120 (SIV gp120) were purchased from SinoBiological. ..

Article Title: Vaccine-induced NA immunity decreases viral shedding, but does not disrupt chains of airborne transmission for the 2009 pandemic H1N1 virus in ferrets
Article Snippet: .. Ferrets that received NA protein were vaccinated intramuscularly (i.m.) with 50 μg of baculovirus-expressed A/California/04/2009 N1 NA recombinant protein (Sino Biological Cat No.11058-V08B) generated with vasodilator-stimulated phosphoprotein tetramerization domain at the N-terminus. .. The recombinant NA protein (specific activity >8,000 pmoles/min/μg using 2'-(4-Methylumbelliferyl)-α-D-N-acetylneuraminic acid substrate and >90% purity by SDS-PAGE) was mixed 1:1 with oil-in-water adjuvant, Sigma Adjuvant System (Sigma Aldrich).

Article Title: Understanding the treatment benefit of hyperimmune anti-influenza intravenous immunoglobulin (Flu-IVIG) for severe human influenza.
Article Snippet: .. Recombinant HA proteins from the A/Cali09 virus and the B/Phuket virus, NA protein from the B/Phuket virus, and a negative control protein simian immunodeficiency virus gp120 (SIV gp120) were purchased from SinoBiological. ..

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Article Title: Preparation of eicosavalent triazolylsialoside-conjugated human serum albumin as a dual hemagglutinin/neuraminidase inhibitor and virion adsorbent for the prevention of influenza infection.
Article Snippet: A triazolylsialoside-human serum albumin conjugate was prepared as a multivalent hemagglutinin and neuraminidase inhibitor using a di-(N-succinimidyl) adipate strategy.. Matrix-Assisted Laser Desorption/IonizationTime of Flight-Mass Spectrometry (MALDI-TOF-MS) indicated that five tetravalent sialyl galactosides were grafted onto the protein backbone resulting in an eicosavalent triazolylsialoside-protein complex.. Compared with monomeric sialic acid, molecular interaction studies showed that the synthetic pseudo-glycoprotein bound tightly not only to hemagglutinin (HA)/neuraminidase (NA) but also to mutated drug-resistant NA on the surface of the influenza virus with a dissociation constant (KD) in the 1 μM range, attributed to the cluster effect.

Article Title: Synthetic pentatrideca-valent triazolylsialoside inhibits influenza virus hemagglutinin/neuraminidase and aggregates virion particles.
Article Snippet: A synthetic multivalent hemagglutinin and neuraminidase inhibitor was developed by the conjugation of a septavalent triazolylsialoside to bovine serum albumin using di-(N-succinimidyl) adipate.. Matrixassisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS) confirmed the attachment of five septavalent sialyl lactosides to the protein backbone, resulting in a pentatrideca-valent sialyl conjugate.. This pseudoglycoprotein demonstrated a high affinity for hemagglutinin/neuraminidase as well as for the drug-resistant NA mutation on the influenza virus surface due to the cluster effect.

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